Search results for "PsyArXiv|Neuroscience|Cognitive Neuroscience"
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Actual and Perceived Motor Competence, Cardiorespiratory Fitness, Physical Activity, and Weight Status in Schoolchildren : Latent Profile and Transit…
2022
Engagement in physical activity plays a central role in the prevention and treatment of childhood overweight/obesity. However, some children may lack the skills and confidence to be physically active. This 3-year follow-up study aimed to form profiles based on cardiorespiratory fitness, actual motor competence, perceived motor competence, physical activity, and weight status, and to examine if these profiles remain stable from late childhood to early adolescence. All these variables were annually assessed in 1,162 Finnish schoolchildren (girls = 583 and boys = 564, Mage = 11.27 ± 0.32 years). Latent profile analysis was used to identify profiles and latent transition analysis to examine the…
Neural Correlates of Age-Related Changes in Precise Grip Force Regulation: A Combined EEG-fNIRS Study
2020
Motor control is associated with suppression of oscillatory activity in alpha (8–12 Hz) and beta (12–30 Hz) ranges and elevation of oxygenated hemoglobin levels in motor-cortical areas. Aging leads to changes in oscillatory and hemodynamic brain activity and impairments in motor control. However, the relationship between age-related changes in motor control and brain activity is not yet fully understood. Therefore, this study aimed to investigate age-related and task-complexity-related changes in grip force control and the underlying oscillatory and hemodynamic activity. Sixteen younger [age (mean ± SD) = 25.4 ± 1.9, 20–30 years] and 16 older (age = 56.7 ± 4.7, 50–70 years) healthy men were…
The relationship between electrophysiological and hemodynamic measures of neural activity varies across picture naming tasks: A multimodal magnetoenc…
2022
Funding Information: This work was financially supported by the Academy of Finland (Finnish Center of Excellence in Computational Inference Research COIN and grants #292334, #294238 to SK; #255349, #315553 to RS; #257576 to JK; #286405 funding for TM), the Sigrid Jusélius Foundation (grant to RS), the Finnish Cultural Foundation (grant to ML), the Swedish Cultural Foundation in Finland (grant to ML), the Maud Kuistila Memorial Foundation (grant to ML), and Aalto Brain Center. Publisher Copyright: Copyright © 2022 Mononen, Kujala, Liljeström, Leppäaho, Kaski and Salmelin. Different neuroimaging methods can yield different views of task-dependent neural engagement. Studies examining the relat…
Transcriptional profiles from patients with dystrophinopathies and limb girdle muscular dystrophies as determined by qRT-PCR.
2003
Mutations in genes coding for the dystrophin-glycoprotein complex (DGC) cause inherited muscular dystrophies (MD), including Morbus Duchenne (DMD) and M. Becker (BMB) as well as limb-girdle muscular dystrophies (LGMD). New insights into the pathophysiology of the dystrophic muscle, the identification of compensatory mechanisms and additional proteins interacting with dystrophin are essential for developing new treatments. In order to define molecular mechanisms induced by lack of dystrophin and the subsequent counter-regulatory transcriptional response of degenerating muscle fibres, we have investigated the mRNA expression of 19 functionally linked genes in biopsies of patients with MD by m…
Movement Variability Increases With Shoulder Pain When Compensatory Strategies of the Upper Body Are Constrained
2017
[DE] This cross-sectional study analyzed the influence of chronic shoulder pain (CSP) on movement variability/kinematics during humeral elevation, with the trunk and elbow motions constrained to avoid compensatory strategies. For this purpose, 37 volunteers with CSP as the injured group (IG) and 58 participants with asymptomatic shoulders as the control group (CG) participated in the study. Maximum humeral elevation (Emax), maximum angular velocity (Velmax), variability of the maximum angle (CVEmax), functional variability (Func_var), and approximate entropy (ApEn) were calculated from the kinematic data. Patients' pain was measured on the visual analogue scale (VAS). Compared with the CG, …
Duodenal contractile activity in dystrophic (mdx) mice: reduction of nitric oxide influence.
2003
The present study was undertaken to analyse duodenal contractility in adult dystrophic (mdx) mice. The spontaneous changes of the isometric tension and the responses of longitudinal duodenal muscle to nonadrenergic, noncholinergic (NANC) nerve stimulation and to exogenous drugs were compared between normal and mdx mice. Duodenal segments from mdx mice displayed spontaneous contractions with higher frequency than normals. N omega-nitro-L-arginine methyl ester (L-NAME) increased the frequency of contractions in normals without affecting that in mdx mice. In normals, NANC nerve stimulation elicited a transient relaxation abolished by L-NAME. In mdx mice a frank relaxation was not observed, the…
Muscleblind, BSF and TBPH are mislocalized in the muscle sarcomere of a Drosophila myotonic dystrophy model
2012
SummaryMyotonic dystrophy type 1 (DM1) is a genetic disease caused by the pathological expansion of a CTG trinucleotide repeat in the 3' UTR of the DMPK gene. In the DMPK transcripts, the CUG expansions sequester RNA-binding proteins into nuclear foci, including transcription factors and alternative splicing regulators such as MBNL1. MBNL1 sequestration has been associated with key features of DM1. However, the basis behind a number of molecular and histological alterations in DM1 remain unclear. To help identify new pathogenic components of the disease, we carried out a genetic screen using a Drosophila model of DM1 that expresses 480 interrupted CTG repeats, i(CTG)480, and a collection of…
A possible susceptibility locus for bipolar affective disorder in chromosomal region 10q25--q26.
2000
In an attempt to identify susceptibility loci for bipolar affective disorder, we are currently conducting a systematic genome screen with highly polymorphic microsatellite markers at an average marker spacing of 10 cM in a series of 75 families, comprising 66 families from Germany, eight families from Israel, and one family from Italy. The families were ascertained through index cases with bipolar affective disorder. The distribution of diagnoses is as follows: 126 individuals with bipolar I disorder, 40 with bipolar II disorder, 14 with schizoaffective disorder of the bipolar type, 40 individuals with recurrent unipolar depression, 51 with a minor psychiatric diagnosis, and two individuals…
Training-induced increase in Achilles tendon stiffness affects tendon strain pattern during running
2019
Background During the stance phase of running, the elasticity of the Achilles tendon enables the utilisation of elastic energy and allows beneficial contractile conditions for the triceps surae muscles. However, the effect of changes in tendon mechanical properties induced by chronic loading is still poorly understood. We tested the hypothesis that a training-induced increase in Achilles tendon stiffness would result in reduced tendon strain during the stance phase of running, which would reduce fascicle strains in the triceps surae muscles, particularly in the mono-articular soleus. Methods Eleven subjects were assigned to a training group performing isometric single-leg plantarflexion co…
Spinal and supraspinal mechanisms affecting torque development at different joint angles
2015
INTRODUCTION We examined the neural mechanisms responsible for plantar flexion torque changes at different joint positions. METHODS Nine subjects performed maximal voluntary contractions (MVC) at 6 ankle-knee angle combinations [3 ankle angles (dorsiflexion, anatomic position, plantar flexion) and 2 knee angles (flexion, full extension)]. Neural mechanisms were determined by V-wave, H-reflex (at rest and during MVC), and electromyography during MVC (RMS), normalized to the muscle compound action potential (V/Msup, Hmax/Mmax, Hsup Msup and RMS/Msup) and voluntary activation (VA), while muscle function was assessed by doublet amplitude. RESULTS MVC and doublet amplitude were significantly low…